Association of polymorphisms of programmed cell death-1 gene with chronic hepatitis B virus infection

作者：Zhang Guoyu; Liu Zhengwen^*; Duan Shaoqiong; Han Qunying; Li Zhu; Lv Yi; Chen Jinghong; Lou Sai; Li Na

来源：Human Immunology, 2010, 71(12): 1209-1213.

DOI：10.1016/j.humimm.2010.08.014

• Programmed cell death-1
• Polymorphism
• Bi PASA
• Chronic HBV infection
• Association

Programmed cell death-1 (PD-1) plays a critical role in regulating T-cell function during hepatitis B virus (HBV) infection The present study investigated the relationships between the polymorphisms of the PD-1 gene and the susceptibility to chronic HBV infection Single nucleotide polymorphisms (SNPs) in PD 1 gene at positions -606G/A (PD-1 1) and +8669 CIA (PD-1 6) were analyzed by bidirectional PCR amplification of specific alleles (Bi-PASA) in 198 chronic HBV patients and 280 controls Although the genotype and allele frequencies of PD-1 1 were not different between chronic HBV patients and controls the genotype and allele frequencies of PD-1 6 were significantly different PD-1 6 GG genotype and the combination of genotypes with G allele were less frequent in HBV patients than in controls (p = 0 007 and p = 0 031 respectively) The allele G was also less frequent in patients than in controls (p = 0 006) Haplotype PD 1 1G/PD-1 6G was less frequent in patients than in controls (p = 0 001) Cirrhosis patients had a lower frequency of PD-1 6 G allele compared with controls (p = 0 007) Our findings firstly reporting the association between PD 1 polymorphism and HBV infection suggest that PD-1 gene

• 出版日期2010-12
• 单位西安交通大学