Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia

作者：Tvarijonaviciute Asta; Eralp Oya; Kocaturk Meric; Yilmaz Zeki; Ceron Jose J^*

来源：Veterinary Immunology and Immunopathology, 2011, 140(1-2): 147-151.

DOI：10.1016/j.vetimm.2010.11.011

• Adiponectin
• CRP
• Hp
• Dog
• Endotoxaemia
• IGF-1

The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.02 mg/kg) and compared with dogs injected with saline solution (0.2 mL/kg). Adiponectin and IGF-1 were both decreased in response to endotoxins in the dog. Significant positive correlations were found between adiponectin and IGF-1 (r = 0.31; p < 0.05). Adiponectin had also a significant negative correlation with CRP (r = 0.39; p < 0.05) and Hp (r = -0.27; p < 0.05), whereas IGF-1 had significant negative correlation with CRP (r = -0.52; p < 0.001).
The results obtained in the present study indicate that adiponectin and IGF-1 behave as negative acute phase proteins after acute inflammatory stimulus in dogs.

• 出版日期2011-3-15