Association Analysis of Dynamin-Binding Protein [DNMBP] on Chromosome 10q With Late Onset Alzheimer's Disease In a Large Caucasian UK Sample

作者：Morean A R^*; Hollingworth P; Abraham R; Lovestone S; Brayne C; Rubinsztein D C; Lynch A; Lawlor B; Gill M; O'Donovan M C; Owen M J; Williams J

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2009, 150B(1): 61-64.

DOI：10.1002/ajmg.b.30768

• late-onset Alzheimer's disease
• DNMBP
• chromosome 10
• association

A recent scan of single nucleotide polymorphisms (SNPs) in the region 40-107 Mb on chromosome 10q in a large Japanese case-control cohort identified six SNPs in or near the dynamin-binding protein gene (DNMBP) that were associated with late onset Alzheimer's disease (LOAD) in individuals lacking the APOE epsilon 4 allele [Kuwano et al. (2006); Hum Mol Genet 15:2170-2182]. We genotyped these six SNPs in 1,212 unrelated Caucasian patients of UK origin with LOAD and 1,389 ethnically, gender and age matched control subjects. We did not observe a statistically significant association with the risk of LOAD for any of the six SNPs in the sample as a whole. When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the epsilon 4 allele (genotypic P = 0.027, allelic P = 0.066). However this association was in the opposite direction to that detected in the Japanese population. It remains to be determined whether DNMBP is associated with LOAD.

• 出版日期2009-1-5
• 单位河北医科大学