Nickel(II) chloride hexahydrate catalyzed reaction of aromatic aldehydes with 2-mercaptoethanol: formation of supramolecular helical assemblage of the product

作者：Laskar Rajibul A; Begum Naznin A; Mir Mohammad Hedayetullah; Rohman Md Rumum; Khan Abu T^*

来源：Tetrahedron Letters, 2013, 54(44): 5839-5844.

DOI：10.1016/j.tetlet.2013.08.070

• Aromatic aldehyde
• 2-Mercaptoethanol Bis(2-hydroxyethyl)dithioacetal 1,3-Oxathiolane
• Nickel(II) chloride hexahydrate (NiCl2.6H(2)O)
• Supramolecular helix

Various aromatic aldehydes on reaction with 2-mercaptoethanol provided an unanticipated product, bis(2-hydroxyethyl)dithioacetals (3) as the major product along with the expected product 1,3-oxathiolanes (4) in the presence of 0.05 equiv amount of nickel(II) chloride hexahydrate (NiCl2-6H(2)O) under solvent-free conditions. Products 3c and 3e exhibit an interesting hydrogen-bonded infinite supra-molecular helical structure.

• 出版日期2013-10-30