科研之友
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摘要
Arterial hypertension is associated with increased risk of occlusive thrombotic events, reflecting a prothrombotic state that is present in hypertensive patients. A number of haemostatic abnormalities appear to play a role in the thrombotic complications of hypertension. Endothelial dysfunction, increased platelet activation, increased activity of the coagulation system, and the decreased function of the fibrinolytic system has been consistently reported in hypertensive patients. These abnormalities can be induced by the activated renin-angiotensin-aldosterone system (RAAS), and may contribute to the increased risk and severity of target organ damage. Antihypertensive treatment by RAAS inhibiting agents could result in a reversal of prothrombotic abnormalities. Since angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) have two distinct mechanisms of RAAS interruption, each therapy might have different impact on the prothrombotic state in hypertensive patients. Some studies demonstrate a beneficial effect, mainly of ACE inhibitors and also partly of some ARBs on the prothrombotic state. The potentially antithrombotic effect of the RAAS inhibiting agents may in turn support the preservation of cardiovascular function. Available data may offer an additional explanation for the efficacy of the RAAS inhibiting agents in the prevention of cardiovascular.
- 出版日期2011-5
