Fast microwave promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and MO(CO)(6) as carbon monoxide sources

作者：Wu XY; Mahalingam AK; Wan YQ; Alterman M^*

来源：Tetrahedron Letters, 2004, 45(24): 4635-4638.

DOI：10.1016/j.tetlet.2004.04.110

• phthalides
• MO(CO)(6)
• carbon monoxide source

A fast method utilizing in situ generated CO for the synthesis of phthalides has been developed. DMF and MO(CO)(6) were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. MO(CO)(6) was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, dihydroisoindone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1 h reaction time.

• 出版日期2004-6-7