In Vitro Activity of Ceftaroline against Staphylococcus aureus Isolates Collected in 2012 from Latin American Countries as Part of the AWARE Surveillance Program

作者：Biedenbach Douglas J; Hoban Daryl J; Reiszner Edina; Lahiri Sushmita D; Alm Richard A; Sahm Daniel F; Bouchillon Samuel K; Ambler Jane E

来源：Antimicrobial Agents and Chemotherapy, 2015, 59(12): 7873-7877.

DOI：10.1128/AAC.01833-15

<jats:title>ABSTRACT</jats:title><jats:p>The<jats:italic>in vitro</jats:italic>activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Staphylococcus aureus</jats:named-content>isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">S. aureus</jats:named-content>(MRSA) percentages ranged from 46% (Brazil) to 62% (Argentina). All methicillin-susceptible<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">S. aureus</jats:named-content>(MSSA) isolates were susceptible to ceftaroline. Ceftaroline activity against MRSA varied with MIC<jats:sub>90</jats:sub>s of 0.5 (Venezuela) to 2 (Brazil, Chile, and Colombia) μg/ml, which was the highest MIC value. ST-5 was the most common sequence type.</jats:p>

• 出版日期2015-12