Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

作者：Walk Seth T; Jain Ruchika; Trivedi Itishree; Grossman Sylvia; Newton Duane W; Thelen Tennille; Hao Yibai; Songer J Glenn; Carter Glen P; Lyras Dena; Young Vincent B; Aronoff David M^*

来源：Anaerobe, 2011, 17(5): 252-256.

DOI：10.1016/j.anaerobe.2011.06.009

• Toxic shock syndrome
• Cholangitis
• Clostridia
• Cytotoxicity
• Sepsis

Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.

• 出版日期2011-10