Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus

作者：Al Hamodi Zaid; AL Habori Molham^*; Al Meeri Ali; Saif Ali Riyadh

来源：Diabetology & Metabolic Syndrome, 2014, 6(1): 99.

DOI：10.1186/1758-5996-6-99

• Type 2 DM
• Obesity
• Adiponectin
• Leptin
• Leptin/Adiponectin ratio
• hs-CRP

Objective: Alterations in plasma adipokines and/or inflammatory parameters in Type 2 DM remain vague as to whether they are due to obesity and/or directly associated with the diabetic state. Our objective was to compare plasma adiponectin, leptin, leptin/adiponectin ratio (LAR) and hs-CRP in obese non-diabetic subjects and non-obese Type 2 DM patients, as well as determining the association of these adipokines with MetS and diabetes-related quantitative traits.
Methods: In this study, 92 Yemeni male volunteers aged 25-60 years old were enrolled, 31 of whom were healthy subjects with BMI < 25 kg/m(2) served as control; 30 non-diabetic obese subjects BMI >= 30 kg/m(2) and FBG <6.1 mmol/l; and 31 non-obese Type 2 DM with FBG >7 mmol/l and BMI < 25 kg/m(2).
Results: Adiponectin was lower in obese subjects, with no differences between non-obese Type 2 DM patients and controls. In contrast, leptin, LAR and hs-CRP were higher in both obese subjects and non-obese Type 2 DM patients. Linear regression analysis showed adiponectin to be associated negatively with BMI, waist circumference, insulin, HOMA-beta and HOMA-IR; whereas leptin, LAR and hs-CRP were associated positively with BMI, waist circumference, TG, FBG, insulin, HOMA-beta and HOMA-IR. Moreover, adiponectin negatively correlated with leptin, LAR and hs-CRP; whereas leptin and LAR positively correlated with hs-CRP and with each other.
Conclusion: Plasma adiponectin is not affected by diabetes per se, suggesting that its alterations in Type 2 DM may be due to obesity and may be an important link between adiposity, IR and Type 2 DM.

• 出版日期2014-9-16