Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats

作者：Ton Tugrul; Ozdemir Ovalioglu Aysegul^*; Ton Ozlem; Bilge Turgay; Kiris Talat

来源：Turkish Neurosurgery, 2013, 23(2): 155-160.

DOI：10.5137/1019-5149.JTN.5893-12.1

• Alpha lipoic acid
• Cerebral vasospasm
• Rat femoral artery
• Subarachnoid hemorrhage

AIM: The dose dependent effects of alpha lipoic acid (alpha-LA) were investigated morphologically on rat vasospasm model. %26lt;br%26gt;MATERIAL and METHODS: 32 rats were divided into four groups: group I=control; group II=vasospasm; group III=vasospasm +low dose (20 mg/kg) intraperitoneal alpha-LA administered; and group IV=vasospasm +high dose (100 mg/kg) intraperitoneal a-LA administered. Histological and morphometric examinations were carried out for each groups under light microscope. %26lt;br%26gt;RESULTS: The mean vascular wall thickness displayed significant increase in group II and III compared with group I (p%26lt;.05). Statistical comparison of group II and IV, regarding vascular wall thickness showed a significant decrease in group IV, and regarding vascular lumen area showed a significant increase in group IV (p%26lt;.05). %26lt;br%26gt;CONCLUSION: It is demonstrated alpha-LA reduces the effects of vasospasm in high dose treatment group by decreasing the wall thickness and increasing the lumen surface area. The present study suggests that adequate dose of a-LA is a potential therapeutic agent in experimental vasospasm model.

• 出版日期2013-3