Association between ERBB4 gene polymorphism in the microRNA binding site and endometrial carcinoma risk

作者：Wang Lingdi; Fang Lei; Cui Yulan^*

来源：Genes & Genomics, 2015, 37(12): 1035-1039.

DOI：10.1007/s13258-015-0336-8

• Endometrial carcinoma
• MicroRNA
• Single nucleotide and polymorphism

The relationship between the single-nucleotide polymorphism (SNP) of ERBB4 gene in the microRNA binding site and the susceptibility of endometrial carcinoma was investigated. A total of 1671 patients with endometrial carcinoma and 1796 healthy controls were enrolled in the study. Genotypes of the ERBB4 gene in the microRNA binding sites at rs1595066 and rs16845990 were then determined using the TaqMan SNP method. The endometrial carcinoma patients and healthy controls showed significant differences in three ERBB4 gene genotypes in the microRNA binding site at rs1595066 (P = 0.044), whereas no difference was observed at the rs16845990 site (P = 0.313). Carriers of the AG and AA genotypes at the rs1595066 site showed lower risk of endometrial carcinoma than the carriers of the GG genotype [odds ratio (OR) = 0.82 and 95 % confidence interval (CI) = 0.70-0.94, and OR = 0.74 and 95 % CI = 0.56-0.94, respectively]. Stratified analysis showed that this protective effect was significant in subjects older than 50 years and those without a history of benign endometrial disease or a family history of cancer. The polymorphism of rs1595066 G > A in the microRNA binding site of the ERBB4 gene is possibly associated with the reduction of endometrial carcinoma risk.

• 出版日期2015-12
• 单位哈尔滨医科大学