Natural History and Retinal Structure in Patients with Usher Syndrome Type 1 Owing to MYO7A Mutation

作者：Lenassi Eva; Saihan Zubin; Cipriani Valentina; Stabej Polona Le Quesne; Moore Anthony T; Luxon Linda M; Bitner Glindzicz Maria; Webster Andrew R^*

来源：Ophthalmology, 2014, 121(2): 580-587.

DOI：10.1016/j.ophtha.2013.09.017

Purpose: To evaluate the phenotypic variability and natural history of ocular disease in a cohort of 28 individuals with MYO7A-related disease. Mutations in the MYO7A gene are the most common cause of Usher syndrome type 1, characterized by profound congenital deafness, vestibular arreflexia, and progressive retinal degeneration.
Design: Retrospective case series.
Participants: Twenty-eight patients from 26 families (age range, 3-65 years; median, 32) with 2 likely disease-causing variants in MYO7A.
Methods: Clinical investigations included fundus photography, optical coherence tomography, fundus autofluorescence (FAF) imaging, and audiologic and vestibular assessments. Longitudinal visual acuity and FAF data (over a 3-year period) were available for 20 and 10 study subjects, respectively.
Main Outcome Measures: Clinical, structural, and functional characteristics.
Results: All patients with MYO7A mutations presented with features consistent with Usher type 1. The median visual acuity for the cohort was 0.39 logarithm of the minimum angle of resolution (logMAR; range, 0.0-2.7) and visual acuity in logMAR correlated with age (Spearman's rank correlation coefficient, r 0.71; P< 0.0001). Survival analysis revealed that acuity <= 0.22 logMAR was maintained in 50% of studied subjects until age 33.9; legal blindness based on loss of acuity (<= 1.00 logMAR) or loss of field (>= 20 degrees) was reached at a median age of 40.6 years. Three distinct patterns were observed on FAF imaging: 13 of 22 patients tested had relatively preserved foveal autofluorescence surrounded by a ring of high density, 4 of 22 had increased signal in the fovea with no obvious hyperautofluorescent ring, and 5 of 22 had widespread hypoautofluorescence corresponding to retinal pigment epithelial atrophy. Despite a number of cases presenting with a milder phenotype, there seemed to be no obvious genotypeephenotype correlation.
Conclusions: MYO7A-related ocular disease is variable. Central vision typically remains preserved at least until the third decade of life, with 50% of affected individuals reaching legal blindness by 40 years of age. Distinct phenotypic subsets were identified on FAF imaging. A specific allele, previously reported in nonsyndromic deafness, may be associated with a mild retinopathy.

• 出版日期2014-2