Antitumor activity of new enantiopure pybox-ruthenium complexes

作者：Menendez Pedregal Estefania; Diez Josefina; Manteca Angel; Sanchez Jesus; Bento Ana C; Garcia Navas Rsula; Mollinedo Faustino; Pilar Gamasa M; Lastra Elena

来源：Dalton Transactions, 2013, 42(38): 13955-13967.

DOI：10.1039/c3dt51160j

New ruthenium complexes containing enantiopure 2,6-bis[4%26apos;(R)-phenyloxazolin-2%26apos;-il-pyridine] ((R,R)-Phpybox), 2,6-bis[4%26apos;(S)-isopropyloxazolin-2%26apos;-il-pyridine] ((S,S)-Pr-i-pybox) or 2,6-bis[4%26apos;(R)-isopropyloxazolin-2%26apos;-il-pyridine] ((R,R)-Pr-i-pybox) and water soluble 1,3,5-triaza-7-phosphaadamantane (PTA) or N-substituted PTA phosphanes have been synthesized in high yields and fully characterized. The interactions of these compounds with plasmidic DNA and their cytotoxic activity against the human cervical cancer HeLa cell line are reported, pointing out for the first time the different behaviour of ruthenium enantiomers affecting the cell cycle in HeLa tumor cells.

• 出版日期2013