Au-Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

作者：Llopis Lorente Antoni; de Luis Beatriz; Garcia Fernandez Alba; Diez Paula; Sanchez Alfredo; Marcos M Dolores; Villalonga Reynaldo^*; Martinez Manez Ramon^*; Sancenon Felix

来源：Journal of Materials Chemistry B, 2017, 5(33): 6734-6739.

DOI：10.1039/c7tb02045g

We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetyl-thiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.

• 出版日期2017-9-7