Development and evaluation of pluronic- and methylcellulose-based thermoreversible drug delivery system for insulin

作者：Nasir Fazli; Iqbal Zafar^*; Khan Amirzada; Khan Jamshaid A; Khan Abad; Khuda Fazli; Zakir Shahida; Yousaf Nageen; Khan Ismail; Shah Yasar; Khan Muhammad Imran; Shahbaz Naila

来源：Drug Development and Industrial Pharmacy, 2014, 40(11): 1503-1508.

DOI：10.3109/03639045.2013.831441

• Insulin
• methylcellulose
• pluronics
• subcutaneous
• thermoreversible in-situ gels

The objective of the current work was to develop and evaluate thermoreversible subcutaneous drug delivery system for Insulin. Thermoreversible in-situ gel system was developed and evaluated both in-vitro and in-vivo comprising of pluronic F-127 alone or in combination with methylcellulose in different ratios. The drug release kinetics and mechanism was predicted by applying various mathematical models to the in-vitro dissolution data. Rabbits were used as animal model following subcutaneous injection to predict various pharmacokinetic parameters by applying Pk-Summit (R) software. The in-vitro and in-vivo data revealed that the formulation IPM 15/3 consisting of the pluronic F-127 (15% w/v) and methylcellulose (3% w/v) was the most robust and capable formulation for extending the drug release and maintaining basal plasma insulin level between 10 and 40 mu U/ml for 240 h (10 d).

• 出版日期2014-11