Morphine sensitivity of spinal neurons in the chronic constriction injury neuropathic rat pain model

作者：Hirsch Silke J^*; Dickenson Anthony H

来源：Neuroscience Letters, 2014, 562: 97-101.

DOI：10.1016/j.neulet.2013.10.007

• Pain
• In vivo electrophysiology
• Morphine
• Chronic constriction injury
• Neuropathy
• Spinal cord

Opioid analgesia involves suppression of neuronal activity in central sensory pathways. We show that the classic opioid morphine reduces spinal neuronal spontaneous and evoked activity after induction of neuropathy by chronic constriction injury of the sciatic nerve in rats. The minimal effective close of morphine was 0.3 mg/kg for most response parameters tested. Morphine sensitivity of spinal cord neurons is similar across neuropathic pain models. We therefore conclude that nerve damage per se rather than the experimental model determines the effectiveness of opioids in general and investigate several pain measurement endpoints which might be important to clinically determine morphine's efficacy in neuropathic pain.

• 出版日期2014-3-6