Novel blood-based microRNA biomarkers for diagnosis of pancreatic cancer: a meta-analysis

作者：Meng, Qing-Cai; Qiu, Wang-Wang; Wen, Zi-Qiang; Wang, Hong-Cheng; Shan, Ze-Zhi; Yuan, Zhou; Huang, Xin-Yu^*

来源：TUMORI JOURNAL, 2015, 101(2): 199-205.

DOI：10.5301/tj.5000240

• Diagnosis
• Meta-analysis
• MicroRNA
• Pancreatic cancer

Background: Recently, several studies have shown that blood-based microRNAs in patients with pancreatic cancer (PC) could be aberrantly expressed. The purpose of this meta-analysis was to evaluate blood-based microRNAs as novel biomarkers for diagnosis of PC.
Methods: Eligible studies which had evaluated the diagnostic performance of blood-based microRNAs and had been published from February 2004 to February 2014 were retrieved. The quality of the studies was evaluated with the QUADAS-2 tool. The performance characteristics were pooled using random-effects models. Statistical analysis was performed with STATA and Meta-Disc1.4 software.
Results: The global meta-analysis included 12 studies from 8 articles, which contained 1,060 blood-based samples of PC patients and 935 blood-based samples of non-PC patients. Summary results suggested pooled sensitivity of 0.87 (95% confidence interval [95% CI], 0.85-0.89), specificity 0.92 (95% CI, 0.90-0.94), positive likelihood ratio 11.18 (95% CI, 5.57-22.46), negative likelihood ratio 0.16 (95% CI, 0.11-0.23), diagnostic odds ratio 88.98 (95% CI, 39.85-198.69) and the area under the summary receiver operating characteristic (SROC) curve 0.96.
Conclusions: This meta-analysis demonstrated blood-based microRNA expression profiles with the potential to discriminate PC patients from non-PC patients, which have moderate diagnostic accuracy. However, further validation studies are needed for their clinical significance in the diagnosis of PC to be established.

• 出版日期2015-4
• 单位上海交通大学