The arginine stimulation test: timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency

作者：Gillis David^*; Granat Nadav; Strich David

来源：Journal of Pediatric Endocrinology & Metabolism, 2013, 26(9-10): 813-817.

DOI：10.1515/jpem-2013-0075

• arginine
• growth hormone deficiency
• short stature

Background: A typical peak timing in the glucagon stimulation test has been reported as an indication of growth hormone (GH) deficiency. Other stimulation tests have not been evaluated.
Objective: To evaluate the clinical usefulness of peak timing in the arginine stimulation test (AST) for growth hormone deficiency.
Methods: Retrospective review of 199 ASTs from one center. Outcomes included correlation of peak times with (a) frequency of deficient peak; (b) growth velocity standard deviation scores (GVSDSs); (c) other evidence of pituitary pathology; (d) results of confirmatory clonidine test; and (e) response to GH treatment.
Results: The peak in 83/109 (76.14%) sufficient tests occurred at typical times vs. 45/72 (62.5%) deficient tests (p < 0.05). GVSDS on GH treatment was greater among patients with typical timing in the AST compared with atypical timing (2.67 +/- 0.59 vs. 0.46 +/- 1.17, p = 0.021). No other variable correlated significantly with AST timing.
Conclusions: Timing of peak in the AST is not a clinically useful parameter.

• 出版日期2013-10