Acute retinal necrosis in the United Kingdom: results of a prospective surveillance study

作者：Cochrane T F; Silvestri G; McDowell C; Foot B; McAvoy C E^*

来源：Eye, 2012, 26(3): 371-377.

DOI：10.1038/eye.2011.338

• acute retinal necrosis
• retinitis
• uveitis
• epidemiology
• herpes viridae

Background To determine the incidence of acute retinal necrosis (ARN) in the United Kingdom and to describe the demographics, management, and visual outcome in these patients. %26lt;br%26gt;Methods This was a prospective study carried out by the British Ophthalmological Surveillance Unit (BOSU) between September 2007 and October 2008. Initial and 6-month questionnaires were sent to UK ophthalmologists who reported cases of ARN via the monthly BOSU report card system. %26lt;br%26gt;Results In all, 45 confirmed cases (52 eyes) of ARN were reported in the 14-month study period, giving a minimum incidence of 0.63 cases per million population per year. There were 20 females and 25 males. Age ranged from 10 to 94 years. Eight patients had a history of herpetic CNS disease. Aqueous sampling was carried out in 13 patients, vitreous in 27, and cerebrospinal fluid (CSF) in 4. Varicella-zoster virus followed by herpes simplex were the most common causative agents. Treatment in 76% of the cases was with intravenous antivirals; however, 24% received only oral antivirals. In all, 47% of patients had intravitreal antiviral therapy. Visual outcome at 6 months was %26lt;6/60 in 48% of the affected eyes. %26lt;br%26gt;Conclusion The minimum incidence of ARN in the UK is 0.63 cases per million. Patients with a history of herpetic CNS disease should be warned to immediately report any visual symptoms. There is increased use of oral and intravitreal antivirals in initial treatment. Eye (2012) 26, 370-378; doi: 10.1038/eye.2011.338; published online 27 January 2012

• 出版日期2012-3