Adipose-Derived Stem Cells Promote Gastric Cancer Cell Growth, Migration and Invasion Through SDF-1/CXCR4 Axis

作者：Zhao Bao Cheng; Zhao Bo; Han Jia Gang; Ma Hua Chong; Wang Zhen Jun^*

来源：Hepato-Gastroenterology, 2010, 58(104): 1382-1389.

• ADSCs
• Gastric cancer cells
• SDF-1
• CXCR4
• Proliferation
• Migration

Background/Aims: The CXCR4/SDF-1 axis regulates the trafficking of various cell types. In the study we investigated whether adipose-derived stem cells can promote gastric cancer cell growth and migration through SDF-1/CXCR4 axis.
Methodology: The expression of CXCR4 in gastric cancer cell line MGC-803 and SDF-1 in Adipose-derived stem cells was detected by using PCR method. Furthermore, cell proliferation, migration and invasion assays were examined and inhibitors of CXCR4 were used to determine the effect on cell migration.
Results: The cells isolated from subcutaneous adipose tissue show characteristics of stem cells. Gastric cancer cells express CXCR4 and Adipose-derived stem cells express SDF-1. Additionally, the tumor cells showed vigorous proliferative and migratory responses to ADSCs. AMD3100 can effectively reduce the migration of gastric cancer cells.
Conclusions: Adipose-derived stem cells can promote gastric cancer cell growth, migration and invasion through SDF-1/CXCR4 axis. CXCR4 can be used in the treatment of gastric cancer as a potential therapeutic target.

• 出版日期2010-12
• 单位首都医科大学