BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: Correlation with biological and clinical features

作者：Bojarska Junak Agnieszka^*; Hus Iwona; Chocholska Sywia; Wasik Szczepanek Ewa; Sieklucka Malgorzata; Dmoszynska Anna; Rolinski Jacek

来源：Leukemia Research, 2009, 33(10): 1319-1327.

DOI：10.1016/j.leukres.2009.03.030

• B-CLL
• BAFF
• APRIL
• ZAP-70
• CD38

B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are involved in normal B cell survival and differentiation. We analyzed BAFF and APRIL plasma levels in patients with B-cell chronic lymphocytic leukemia (B-CLL). We also tested intracellular BAFF and APRIL expression in B-CLL and evaluated their prognostic relevance. The percentage of leukemic B cells with intracellular APRIL or BAFF expression correlated significantly with adverse prognostic factors such as ZAP-70 and CD38. Moreover, we found a close relationship between LPL protein expression or LPL/ADAM29 MFI ratio and proportion of B-CLL cells with intracellular BAFF or APRIL expression. Furthermore, patients with a low percentage of leukemic cells with intracellular BAFF or APRIL expression had a significantly longer overall survival than those with a high proportion of APRIL or BAFF positive leukemic cells.

• 出版日期2009-10