科研之友
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摘要
Purpose: To characterize peritoneal carcinomatosis (PC) of different histologically proven primary tumors based on diffusion-weighted imaging (DWI) and 18 F-FDG positron emission tomography (PET). Materials and Methods: Forty-one patients underwent simultaneous MR/PET after clinically indicated 18 F-FDGPET/CT. For all patients, histology of the primary tumor was obtained. MR protocol comprised anatomical imaging and axial DWI. Apparent diffusion coefficient (ADC) maps and FDG-PET were co-registered for evaluation of ADC and standard uptake value (SUV) of peritoneal lesions. Both lesion-and patient-based analysis was performed. Up to four peritoneal lesions were evaluated per patient. Mean and maximum standard uptake value (SUVmean, SUVmax), mean and minimum ADC (ADCmean, ADCmin) of each lesion were assessed. Spearman rank correlation (rs) of ADC and SUV were calculated. SUV and ADC of ovarian and colorectal cancer lesions were compared using Wilcoxon test. Results: Measurable lesions (n = 52) were found in 20 of 41 PC patients. Moderate, but significant correlation existed between ADC and SUV in the lesion-based as well as the patient-based analysis (lesion-based: SUVmean versus ADC(mean) r(s) = -0.58; SUVmax versus ADC(min) r(s) = -0.56, all P %26lt; 0.0001; patient-based: SUVmean versus ADC(mean) r(s) = -0.64, P = 0.002; SUVmax versus ADCmin rs = -0.60, P = 0.005). ADC and SUV differed significantly between ovarian and colorectal cancer lesions (ADCmin: P %26lt; 0.0001; ADC(mean): P %26lt; 0.0001; SUVmax: P = 0.002; SUVmean: P = 0.005). Overall, mucinous tumor entities showed a tendency to higher ADC and lower SUV. Conclusion: PC lesions showed significant differences in glucose uptake and diffusion characteristics depending on primary tumor histology. These differences should be considered when interpreting FDG-PET and DWI in PC patients.
- 出版日期2014-11
