科研之友
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摘要
A series of chiral N-phosphonyl protected alpha-alkenyl homoallylic primary amines were synthesized by asymmetric addition of allylmagnesium bromide to chiral alpha,beta-unsaturated imines. Only the 1,2-adduct was obtained for all the imines with good yields and excellent diastereoselectivities. The chiral auxiliary could be easily removed under simple conditions, giving free multiple functionalized primary amines.
- 出版日期2013
- 单位南京大学
