Short- and Long-Term Outcomes of Acute Severe Ulcerative Colitis in Korea: The 1999-2005 Cohort

作者：Lee Ho Su; Yang Suk Kyun^*; Soh Jae Seung; Lee Seohyun; Bae Jung Ho; Lee Hyo Jeong; Park Sang Hyoung; Yang Dong Hoon; Kim Kyung Jo; Ye Byong Duk; Byeon Jeong Sik; Myung Seung Jae; Yoon Yong Sik; Yu Chang Sik; Kim Jin Ho

来源：Inflammatory Bowel Diseases, 2015, 21(8): 1825-1831.

DOI：10.1097/MIB.0000000000000447

• acute severe ulcerative colitis
• colectomy
• treatment
• outcome
• Korea

Background:No previous studies have evaluated the long-term outcomes of acute severe ulcerative colitis (ASUC) in non-Caucasian populations. The purposes of this study were to evaluate the short- and long-term outcomes of Korean patients with ASUC.Methods:We retrospectively analyzed 99 Korean patients with ASUC who satisfied the criteria given by Truelove and Witts between 1999 and 2005. The short-term outcome parameter was the colectomy rate during index hospitalization, and the long-term outcome parameters were the rates of colectomy and rehospitalization after discharge from index hospitalization.Results:During index hospitalization, 16 of 99 patients (16.2%) underwent colectomy: 6 of 71 responders (8.5%) to intravenous steroids on day 3 versus 10 of 28 nonresponders (35.7%), as assessed using the Oxford index (P = 0.002). Among 83 patients who avoided colectomy during index hospitalization, 13 patients (15.7%) underwent colectomy during the median follow-up period of 10.6 years. The cumulative probability of colectomy tended to be lower in complete responders on day 7 of intravenous steroid therapy (CR7) than in others: 3.7% versus 13.9% at 5 years and 7.6% versus 18.2% at 10 years (P = 0.100). The cumulative probability of rehospitalization was significantly lower in CR7 than in other patients: 20.5% versus 37.5% at 5 years and 31.4% versus 48.2% at 10 years (P = 0.043).Conclusions:Assessing the degree of response to intravenous steroids helps predict the short- and long-term outcomes in patients with ASUC. Korean patients with ASUC may have better clinical courses than Caucasians, as indicated by the lower colectomy rate.

• 出版日期2015-8