A study on the synthesis and properties of substituted EHBG-Fe(III) complexes as potential MRI contrast agents

作者：Kuznik Nikodem^*; Szafraniec Gorol Grazyna; Oczek Lidia; Grucela Artur; Jewula Pawel; Kuznik Anna; Zassowski Pawel; Domagala Wojciech

来源：Journal of Organometallic Chemistry, 2014, 769: 100-105.

DOI：10.1016/j.jorganchem.2014.07.011

• Fe(III) complexes
• EHBG
• N,N'-ethylenebis[(2-hydroxybenzyl)glycine]
• HBED
• N,N'-di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid
• Contrast agents
• Relaxivity
• EPR

Mono- and disubstituted EHBG (HBED) ligands of different kind: forming hydrogen bonds (p-OMe, p-NHAc) and of high lipophilicity (3,4-Me-2, p-Ph) were obtained. The ligands were complexed with Fe(III). Complexes so obtained were studied for their stability in different pH environments; and r(1) relaxivity, which turned out the highest for Fe-EHBG-NHAc, i.e. 0.95 mM(-1) s(-1) in aqueous solution and 1.34 mM(-1) s(-1) for Fe-EHBG-Me-2 in bovine serum. EPR signals were observed at g-factor of 4.27 indicative of Kramer's doublet transitions of a rhombically distorted high-spin paramagnetic center.

• 出版日期2014-10-15