Emerging tools for synthetic genome design

作者：Lee Bo Rahm; Cho Suhyung; Song Yoseb; Kim Sun Chang; Cho Byung Kwan^*

来源：Molecules and Cells, 2013, 35(5): 359-370.

DOI：10.1007/s10059-013-0127-5

• genome
• genome editing
• next-generation sequencing
• synthetic biology

Synthetic biology is an emerging discipline for designing and synthesizing predictable, measurable, controllable, and transformable biological systems. These newly designed biological systems have great potential for the development of cheaper drugs, green fuels, biodegradable plastics, and targeted cancer therapies over the coming years. Fortunately, our ability to quickly and accurately engineer biological systems that behave predictably has been dramatically expanded by significant advances in DNA-sequencing, DNA-synthesis, and DNA-editing technologies. Here, we review emerging technologies and methodologies in the field of building designed biological systems, and we discuss their future perspectives.

• 出版日期2013-5