An efficient synthesis of (3-indolyl)acetonitriles by reduction of hydroxamic acids

作者：Aksenov Alexander V^*; Aksenov Nicolai A; Dzhandigova Zarema V; Aksenova Inna V; Voskressensky Leonid G; Smirnov Alexander N; Rubin Michael A^*

来源：Chemistry of Heterocyclic Compounds, 2016, 52(5): 299-302.

DOI：10.1007/s10593-016-1881-z

• hydroxamic acids
• indoles
• nitriles
• reduction

A new, highly efficient method was developed for the synthesis of (3-indolyl)acetonitriles by reduction of readily available (3-indolyl)hydroxamic acids with phosphorus trichloride. The nitriles obtained according to this method are of significant interest for structure-activity studies of potential anticancer agents.

• 出版日期2016-5