Association between non-alcoholic fat liver disease and liver function/injury markers with metabolic syndrome components in class III obese individuals

作者：Chaves Gabriela Villaca^*; de Souza Daiane Spitz; Pereira Silvia Elaine; Saboya Carlos Jose; Ferreira Peres Wilza Arantes

来源：Revista da Associacao Medica Brasileira, 2012, 58(3): 288-293.

• Fatty liver
• metabolic syndrome X
• obesity

Association between non-alcoholic fat liver disease and liver function/injury markers with metabolic syndrome components in class Ill obese individuals %26lt;br%26gt;Objective: To investigate the association between non-alcoholic fatty liver disease (NAFLD) and liver function/injury markers with components of metabolic syndrome (MS) in class III obese individuals. Methods: The study population consisted of 144 patients with class III obesity (body mass index [BMI] %26gt;= 40 kg/m(2)). MS was diagnosed according to the National Cholesterol Education Program - Adult Treatment Panel III (NCEP ATP III) criteria, by determining the lipid profile, blood glucose and basal insulin. Liver function/injury markers were also quantified. Insulin resistance (IR) was measured by HOMA-IR and NAFLD diagnosis was established by magnetic resonance imaging (MRI). Statistical calculations were performed by SPSS version 13.0. The association was assessed by the Mann-Whitney and Chi-square tests, with a level of significance set at 5%. Results: There was a significant association between the diagnosis of MS and NAFLD (chi(2) = 6.84, p = 0.01). As for the diagnostic components of MS, there was a positive and significant association between HDL-C (p = 0.05), waist circumference (p %26lt; 0.05) and hypertension (chi(2) = 4.195, p = 0.041) with NAFLD. HOMA-IR (p %26lt; 0.001) also showed a positive association with liver disease. Conclusion: A positive and significant association between NAFLD and components of metabolic syndrome in class III obese individuals was observed, suggesting the need and importance of monitoring these components for NAFLD screening.

• 出版日期2012-6