Adherence Patterns With First- Versus Second-Generation Antipsychotics for Newly Diagnosed Schizophrenia in Taiwan

作者：Chang Chia Ming; Wu Kuan Yi; Liang Hsin Yi; Wu Erin Chia Hsuan; Chen Chuan Yu; Wu Chi Shin; Chen Shaw Ji; Chang Tsung Kai; Tsai Hui Ju^*

来源：Psychiatric Services, 2012, 63(5): 504-507.

DOI：10.1176/appi.ps.201100011

Objective: The aim of this study was to compare the early adherence patterns for first-generation antipsychotics and second-generation antipsychotics during the first month of treatment for patients newly diagnosed as having schizophrenia. Methods: With a random sample from the Taiwan national health insurance database, persons with a schizophrenia diagnosis (ICD-9-CM code 295.X) and a concurrent initial antipsychotic prescription from 1998 to 2006 were defined as being newly treated for schizophrenia. Adherence patterns within one month of diagnosis were categorized into four independent groups: refill, switch, admission, and discontinuation. Results: Treatment initiated with first-generation or second-generation antipsychotics resulted in similar rates of refill (57% versus 59%). However, patients who started with first-generation antipsychotics were significantly less likely to switch (9% versus 14%) but more likely to discontinue (34% versus 26%) medications than those whose treatment was initiated with second-generation antipsychotics. Conclusions: The data substantiated previous observations of the magnitude of adherence problems in Asian populations and highlight the importance of developing new strategies for intervention. (Psychiatric Services 63:504-507, 2012; doi: 10.1176/appi.ps.201100011)

• 出版日期2012-5
• 单位长春大学; 西北大学