Membrane-drug interactions studied using model membrane systems

作者:Knobloch Jacqueline; Suhendro Daniel K; Zieleniecki Julius L; Shapter Joseph G; Koeper Ingo
来源:Saudi Journal of Biological Sciences, 2015, 22(6): 714-718.
DOI:10.1016/j.sjbs.2015.03.007

摘要

The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.

  • 出版日期2015-11