A New and Practical Synthesis of Vortioxetine Hydrobromide

作者：Mao, Yongjun; Jiang, Luobin; Chen, Tianyun; He, Haijun; Liu, Gang; Wang, Han^*

来源：Synthesis (Germany), 2015, 47(10): 1387-1389.

DOI：10.1055/s-0034-1380505

• vortioxetine hydrobromide
• new route
• synthetic process
• atypical antidepressant
• green chemistry

A new and improved synthetic route to vortioxetine hydrobromide is established on a hectogram scale through three simple steps in 63% yield and with 99% purity (HPLC). The key step is the cyclization of the piperazine ring in the final step. Purification methods for the intermediates involved in the route are given.

• 出版日期2015-5
• 单位上海工程技术大学