Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis

作者:Zhan Xianbao; Wang Fan; Bi Yan; Ji Baoan
来源:American Journal of Physiology - Gastrointestinal and Liver Physiology, 2016, 311(3): G343-G355.
DOI:10.1152/ajpgi.00372.2015

摘要

<jats:p> Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity. Autoimmune pancreatitis and genetically engineered animal models will be reviewed elsewhere. </jats:p>

  • 出版日期2016-9-1
  • 单位Mayo Clinic; Mayo clinic