Protective effects of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates against hepatic ischemia/reperfusion injury in vivo

作者：Hanawa Tomochika; Asayama Shoichiro; Watanabe Taiji; Owada Shigeru; Kawakami Hiroyoshi^*

来源：Journal of Controlled Release, 2009, 135(1): 60-64.

DOI：10.1016/j.jconrel.2008.12.012

• Superoxide dismutase mimic
• Manganese porphyrin
• Catalase-poly(ethylene glycol) conjugate
• Hepatic ischemia/reperfusion injury
• Antioxidative activity

The complex between manganese (Mn) porphyrins and catalase-poly(ethylene glycol) (PEG) conjugates has been designed for the protective effect against hepatic ischemia/reperfusion injury in vivo. The resulting Mn-porphyrin/catalase-PEG complex with dual enzymatic activity of superoxide dismutase (SOD) and catalase enhanced the blood circulation. The spin reduction rate in the rats treated with the Mn-porphyrin/catalase-PEG complex was significantly higher than that in the untreated rats and almost equal to that in the sham group rats. Furthermore, the Mn-porphyrin/catalase-PEG complex significantly decreased the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. These results suggest that the Mn-porphyrin/catalase-PEG complex exhibited the antioxidative activity to protect hepatic ischemia/reperfusion injury in vivo.

• 出版日期2009-4-2