An unconventional BST-2 function: Down-regulation of transient protein expression

作者：Narkpuk Jaraspim; Wanitchang Asawin; Kramyu Jarin; Frantz Phanramphoei Namprachan; Jongkaewwattana Anan; Teeravechyan Sama****^*

来源：Biochemical and Biophysical Research Communications, 2014, 450(4): 1469-1474.

DOI：10.1016/j.bbrc.2014.07.022

• BST-2
• Tetherin
• Influenza virus
• Reverse genetics
• Protein expression

While viral inhibition by tethering of budding virions to host cell membranes has been focused upon as one of the main functions of BST-2/tetherin, BST-2 is thought to possess other functions as well. Overexpression of BST-2 was found here to down-regulate transient protein expression. Removal of the N- and C-terminal regions of BST-2, previously described to be involved in signal transduction, reduced the impact of BST-2. These results suggest that BST-2-mediated signaling may play a role in regulating the levels of transiently expressed proteins, highlighting a new function for BST-2 that may also have implications for viral inhibition.

• 出版日期2014-8-8