Differential effects of Co(III), Ni(II), and Ru(III) amine complexes on Sindbis virus

作者：Knight D Andrew; Hickey Thomas E; Bongard Jason E; Thach Dzung C; Yngard R; Chang Eddie L^*

来源：Journal of Inorganic Biochemistry, 2010, 104(5): 592-598.

DOI：10.1016/j.jinorgbio.2010.01.012

• Hexaamminecobalt(III) chloride
• Anti-viral
• Metal complexes
• Broad-spectrum drug

Transition metal complexes [Co(cyclen)(NH(3))(2)](ClO(4))(3)center dot H(2)O (cyclen = 1,4,7,10-tetraazacyclododecane) (2), [Co(NH(3))(5)(OH(2))](CF(3)SO(3))(3) (3) [Ni(NH(3))(6)]Br(2) (4) and [Ru(NH(3))(6)]Cl(3) (5) were tested against Sindbis infected baby hamster kidney (BHK) cells and show differential effects from the previously reported anti-viral complex [Co(NH(3))(6))Cl(3) (1). The macrocyclic complex 2 and labile aqua complex 3 show either no or little effect on the survival on Sindbis virus-infected cells as compared to that for 1, which show a monotonic increase in % BHK cell survival. Nickel and ruthenium ammine complexes 4 and 5 had a moderate influence of cell survival. While the results showed some anti-viral activity for some of the structural variations, it appears that 1, with its potential to be a broad-spectrum anti-viral compound, occupies a unique position in its ability to both significantly enhance cell survival and to decrease viral expression of infected cells. We also show that 1 also shows anti-viral activity against Adenovirus lending support to the broad-spectrum potential of this complex. Published by Elsevier Inc.

• 出版日期2010-5