A novel approach for highly regio- and stereoselective synthesis of (Z)-3-methyleneisoindoline-1-ones in aqueous micellar medium

作者：Sarkar Swarbhanu; Dutta Samrat; Dey Rajdip; Naskar Subhendu^*

来源：Tetrahedron Letters, 2012, 53(50): 6789-6792.

DOI：10.1016/j.tetlet.2012.10.001

• (Z)-3-Methyleneisoindoline-1-one
• Cu-free Sonogashira
• 5-Exo-dig cyclization
• Micelle
• Reaction in water

An environmentally benign and operationally simple methodology was developed for the regio- and stereoselective synthesis of (Z)-3-methyleneisoindolinones in aqueous micellar medium from 2-iodo-N-phenyl-benzamides and terminal alkyne by Cu-free domino Sonogashira reaction followed by 5-exo-dig-cyclization using Pd(CH3CN)Cl-2 as catalyst and 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene as ligand under aerobic condition.

• 出版日期2012-12-12