Advantages of collecting multiple urinary iodine concentrations when assessing iodine status of a population

作者：Samidurai A J^*; Ware R S; Davies P S W

来源：Acta Paediatrica, 2015, 104(11): E524-E529.

DOI：10.1111/apa.13168

• Children
• Iodine
• Iodine status surveillance
• Urinary iodine concentration

AimTo evaluate the effect of collecting multiple (four) urine samples on the extensive variance often observed within a cohort when determining iodine status via urinary iodine concentration (UIC).
MethodsFifty-one children aged two to three years and thirty children aged 8-10years participated in the study in South East Queensland, Australia. Each child's four urine samples were analysed using ammonium persulphate digestion before a Sandell-Kolthoff reaction method. Analysis of variance techniques were used to assess the effect of using multiple urine samples.
ResultsThe median UICs were 223.3 and 141g/L for two- to three-year-olds and eight- to 10-year-olds, respectively. The coefficient of variance (CV) of UIC for children aged two to three years was reduced by 35.6%, 36.5% and 39.7% when two, three and four samples were included in the adjustment, respectively. Similarly, the CV of UIC for children aged 8-10years was reduced by 24.7%, 30.7% and 34.7%, respectively.
ConclusionAlthough the practicality and cost of collecting multiple UICs need to be considered, collecting multiple UIC samples from each participant provides a more accurate reflection of a cohort iodine status.

• 出版日期2015-11