Nutritional and biochemical parameters associated with 6-year change in bone mineral density in community-dwelling Japanese women aged 69 years and older: The Muramatsu Study

作者：Nakamura Kazutoshi^*; Oyama Mari; Saito Toshiko; Oshiki Rieko; Kobayashi Ryosaku; Nishiwaki Tomoko; Nashimoto Mitsue; Tsuchiya Yasuo

来源：Nutrition, 2012, 28(4): 357-361.

DOI：10.1016/j.nut.2011.05.013

• Albumin
• Bone density
• Cohort studies
• Elderly
• Nutrition
• Vitamin D

Objective: Predictors of bone loss in elderly Asian women have been unclear. This cohort study aimed to assess lifestyle, nutritional, and biochemical predictors of bone loss in elderly Japanese women. %26lt;br%26gt;Methods: Subjects included 389 community-dwelling women aged 69 y and older from the Muramatsu cohort initiated in 2003; follow-up ended in 2009. We obtained data on physical characteristics, osteoporosis treatment (with bisphosphonates or selective estrogen receptor modulators), physical activity, calcium intake, serum 25-hydroxyvitamin D. undercarboxylated osteocalcin, serum albumin, and bone turnover markers as predictors. The outcome was a 6-y change in forearm BMD (Delta BMD). Osteoporosis treatment was coded as 0 for none, 1 for sometimes, and 2 for always during the follow-up period. Stepwise multiple linear regression analysis was used to identify independent predictors of Delta BMD. %26lt;br%26gt;Results: Mean age of the subjects was 73.3 y. Mean values of Delta BMD and Delta weight were 0.019 g/cm(2) (-5.8%) and -2.2 kg, respectively. Stepwise multiple linear regression analysis revealed baseline BMD (beta = 0.137, P %26lt; 0.0001), osteoporosis treatment beta = 0.0068, P = 0.0105), serum albumin levels (beta = 0.0122, P = 0.0319), and Delta weight (beta = 0.0015, P = 0.0009) as significant independent predictors of Delta BMD. However, none of the other nutritional or biochemical indices were found to be significant predictors of Delta BMD. %26lt;br%26gt;Conclusions: Our findings indicate that adequate general nutrition and appropriate osteoporosis medication, rather than specific nutritional regimens, may be effective in preventing bone loss in elderly women.

• 出版日期2012-4