Base-controlled 1,6-enyne-bicyclization: divergent synthesis of benzo[b]fluorenones and benzo[b]fluorenols

作者：Hao, Wen-Juan; Zhou, Peng; Yang, Zheng; Jiang, Bo^*; Zhang, Jin-Peng; Tu, Shu-Jiang^*

来源：Tetrahedron, 2016, 72(17): 2206-2212.

DOI：10.1016/j.tet.2016.03.026

• 1,6-Enyne-bicyclization
• Benzo[b]fluorenones
• Benzo[b]fluorenols
• Metal-free reaction
• Chemoselectivity

An interesting base-controlled protocol for the divergent and atom-economic synthesis of benzo[b]fluorenones and benzo[b]fluorenols with the great diversity in substitution patterns has been developed. Started from readily available 1,6-enynes, good to excellent yields of the corresponding tetracyclic benzo [b]fluorenones and benzo[b]fluorenols can be chemoselectively achieved under metal-free conditions. Notably, only K2CO3 or Et3N was required as the promoter here and the reaction can work well in a high selective manner.

• 出版日期2016-4-28
• 单位江苏师范大学; 徐州医科大学