Brain perfusion SPECT correlates with CSF biomarkers in Alzheimer's disease

作者：Habert Marie Odile^*; de Souza Leonardo Cruz; Lamari Foudil; Daragon Nelle; Desarnaud Serge; Jardel Claude; Dubois Bruno; Sarazin Marie

来源：European Journal of Nuclear Medicine and Molecular Imaging, 2010, 37(3): 589-593.

DOI：10.1007/s00259-009-1285-8

• SPECT
• rCBF
• Alzheimer's disease
• Mild cognitive impairment
• CSF biomarkers

Our aim was to study the correlations between cerebrospinal fluid (CSF) biomarker levels such as beta-amyloid 42 (A beta(42)), total and phosphorylated tau protein (T-tau and P-tau) and brain perfusion SPECT in Alzheimer's disease (AD) using a voxel-based methodology.
Patients (n = 31) with clinical features of AD (n = 25) or amnestic mild cognitive impairment (aMCI) (n = 6) were retrospectively included. All subjects underwent the same clinical, neuropsychological and neuroimaging tests. They had a lumbar puncture and a brain perfusion ((99m)Tc-ECD) SPECT within a time interval of 10 (+/- 26) days. Correlations between CSF biomarker concentrations and perfusion were studied using SPM2 software. Individual normalised regional activity values were extracted from the eligible clusters for calculation of correlation coefficients.
No significant correlation was found between A beta(42) concentrations and brain perfusion. A significant correlation (p < 0.01, corrected) was found between T-tau or P-tau concentrations and perfusion in the left parietal cortex.
Our results suggest a strong correlation between T-tau and P-tau levels and decreased brain perfusion in regions typically affected by neuropathological changes in AD.

• 出版日期2010-3