Amidines for Versatile Cobalt(III)-Catalyzed Synthesis of Isoquinolines through C-H Functionalization with Diazo Compounds

作者：Li, Jie^*; Tang, Mengyao; Zang, Lei; Zhang, Xiaolei; Zhang, Zhao; Ackermann, Lutz^*

来源：Organic Letters, 2016, 18(11): 2742-2745.

DOI：10.1021/acs.orglett.6b01199

• N-TYPE REACTIONS
• DIRECTED FUNCTIONALIZATION
• UNPROTECTED INDOLES
• SELECTIVE ACCESS
• BOND ACTIVATION
• AMIDATION
• ARENES
• CYANATION
• ALKYNES
• ALKENYLATIONS

A cobalt(III),-catalyzed C-H/N-H bond functionalization for the synthesis of 1-aniinoisoquincilines from aryl amidines and diazo compounds has been developed: The reaction proceeds under mild reaction conditions, obviates the need for oxidants, produces only N-2 and H2O as the byproducts, and features a broad substrate scope.

• 出版日期2016-6-3
• 单位江南大学