A Simple alpha-Ketoglutarate Electrochemical Biosensor Based on Reduced MoS2 Nanoparticle-Gold Nanoparticle Nanocomposite

作者：Yu Yadong; Wu Na; Peng Gang; Li Tao; Jiang Ling; Huang He

来源：Journal of Nanoscience and Nanotechnology, 2018, 18(1): 576-582.

DOI：10.1166/jnn.2018.13945

• alpha-Ketoglutarate
• MoS2
• Gold Nanoparticle
• Electrochemical Sensing

Convenient and sensitive methods for the detection of alpha-ketoglutarate (alpha-KG) will be beneficial for biomedical diagnosis and microbial fermentation industry. In this work, reduced MoS2 nanoparticles (rMNs) were prepared by ultrasonication and electrochemical reduction. The rMNs were then decorated with gold nanoparticles (Au-nano) to fabricate rMNs-Au-nano nanocomposite. The glass carbon electrode modified with rMNs-Au-nano nanocomposite (rMNs-Au-nano-GCE) showed excellent electro-catalytic oxidation toward NADH with a satisfied reproducibility and exhibited linear response in the range of 38.46-214.29 mu M. Moreover, the L-Glutamic dehydrogenase modified rMNs-Au-nano-GCE exhibited a sensitive and fast response to alpha-KG, with a linear response range of 11.12-52.94 mu M and a detection limit of 6.25 mu M. These findings will pave ways for the alpha-KG detection and the application of MoS2 or other two-dimensional materials in electrochemical sensing.

• 出版日期2018-1