Association of Interleukin 2 (IL-2), Interleukin 6 (IL-6), and TNF-alpha (TNF alpha) Gene Polymorphisms With Paranoid Schizophrenia in a Polish Population

作者：Paul Samojedny Monika^*; Owczarek Aleksander; Kowalczyk Malgorzata; Suchanek Renata; Palacz Marta; Kucia Krzysztof; Fila Danilow Anna; Borkowska Paulina; Kowalski Jan

来源：Journal of Neuropsychiatry and Clinical Neurosciences, 2013, 25(1): 72-82.

DOI：10.1176/appi.neuropsych.12020021

Numerous reports have brought attention to the potential role of cytokines in schizophrenia. The aim of the study was to determine whether polymorphisms of IL-2, IL-6, and TNF alpha genes are risk factors for development of paranoid schizophrenia in a Polish population. Promoter polymorphisms of IL-6 (rs1800795), TNF alpha (rs1800629), and IL-2 (rs2069762) genes in patients (N = 115) and controls (N = 135) were genotyped by PCR-RFLP and AS-PCR methods, respectively. Genotype TT and allele T for IL-2 polymorphism, and genotype AA and allele A for TNF alpha polymorphism were found to be significantly associated with paranoid schizophrenia. Similarly, haplotypes CTA and GTA increased the risk (4.4 times and 5.9 times, respectively) of schizophrenia. To reveal associations between Positive and Negative Symptom Scale subscales and age at onset of schizophrenia, the authors used a novel method called Grade Correspondence Analysis. This analysis revealed that patients with early age at onset have higher scores on the Negative and General subscales of PANSS, and, in that group of patients, haplotype CTA was the most represented. As far as is known, this analysis was used for the first time with reference to genetic data. (The Journal of Neuropsychiatry and Clinical Neurosciences 2013; 25:72-82)

• 出版日期2013