Atrial natriuretic peptide and cardiac troponin I concentrations in healthy Warmblood horses and in Warmblood horses with mitral regurgitation at rest and after exercise

作者：Trachsel Dagmar S^*; Schwarzwald Colin C; Bitschnau Caroline; Grenacher Beat; Weishaupt Michael A

来源：Journal of Veterinary Cardiology, 2013, 15(2): 105-121.

DOI：10.1016/j.jvc.2012.12.003

• Equine
• Cardiac biomarkers
• Exercise capacity
• Pulmonary wedge pressure

Objective: Atrial natriuretic peptide (ANP) and cardiac troponin I (cTnI) serve as biomarkers for increased cardiac pressure/volume loading and for myocardial stress or damage. The objective was to describe the time course of plasma ANP concentrations (Cp-ANP) and plasma cTnI concentrations (CDcTnI) in horses with mitral regurgitation (MR) compared to healthy horses at rest and after exercise, and to describe the relationship of Cp-ANP with cardiac dimensions and intracardiac pressures. %26lt;br%26gt;Animals: 15 healthy Warmblood horses and 7 Warmblood horses with MR. %26lt;br%26gt;Methods: Cardiac dimensions at rest were measured using echocardiography. All horses underwent standardized treadmill exercise. Biomarker concentrations and intracardiac pressures were measured at rest and after exercise. Hypotheses were tested using statistical methods. The level of significance was P %26lt; 0.05. %26lt;br%26gt;Results: Horses with MR showed increased left atrial (LA) and left ventricular (LV) dimensions but similar exercise capacity compared to healthy horses. Pulmonary capillary wedge pressures (PCWP) and Cp-ANP increased with exercise. Horses with MR had higher PCWP and higher Cp-ANP at rest and after exercise compared to healthy horses, with the maximum difference in Cp-ANP reached 10 min after exercise. Cp-ANP was significantly related to PCWP and - although inconsistently and only in healthy horses - to echocardiographic indices of LA and LV size and function. CPcTnI was low throughout the study in both groups. %26lt;br%26gt;Conclusions: Cp-ANP is increased in horses with MR and is related to LA pressures and to left heart dimensions. MR is not necessarily associated with exercise intolerance and exercise-induced myocardial stress or damage.

• 出版日期2013-6