Antimicrobial resistance, biofilm formation and virulence reveal Actinobacillus pleuropneumoniae strains' pathogenicity complexity

作者：Pereira Monalessa Fabia; Rossi Ciro Cesar; Seide Larissa Eler; Martins Filho Sebastiao; Dolinski Claudia de Melo; Soares Bazzolli Denise Mara

来源：Research in Veterinary Science, 2018, 118: 498-501.

DOI：10.1016/j.rvsc.2018.05.003

• Porcine pleuropneumonia
• Pasteurellaceae
• Galleria mellonella

Porcine pleuropneumonia is an important cause of lowered productivity and economic loss in the pig industry worldwide, associated primarily with Actinobacillus pleuropneumoniae infection. Its colonization and persistence within the upper respiratory tract of affected pigs depends upon interactions between a number of genetically controlled virulence factors, such as pore-forming repeats-in-toxin exoproteins, biofilm formation, and antimicrobial resistance. This study investigated correlations between biofilm-forming capacity, antimicrobial resistance, and virulence of A. pleuropneumoniae obtained from clinical outbreaks of disease, using a Galleria mellonella alternative infection model. Results suggest that virulence is diverse amongst the 21 strains of A. pleuropneumoniae examined and biofilm formation correlated with genetic control of antimicrobial resistance.

• 出版日期2018-6