Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells

作者：Zhou Jianjun; Feigenbaum Lionel; Yee Carole; Song Hongbin^*; Yates Clayton

来源：Biomed Research International, 2013, 2013: 913179.

DOI：10.1155/2013/913179

Prostate stem cells are thought to be responsible for generation of all prostate epithelial cells and for tissue maintenance. The lineage relationship between basal and luminal cells in the prostate is not well clarified. We developed a mouse model to trace cell fate and a mouse model with a slowly cycling cell label to provide insight into this question. The results obtained indicate that putative mouse prostate stem cells are likely to reside in the basal layer.

• 出版日期2013
• 单位中国人民解放军军事医学科学院