A facile and efficient synthesis of 1-trichloromethyl-1,2-dihydrobenzo[b][1,6]naphthyridines via three-component reaction among 2-alkynylquinoline-3-carbaldehydes, primary amines, and chloroform

作者：Buksnaitiene Rita; Cikotiene Inga^*

来源：Heterocyclic Communications, 2012, 18(2): 87-92.

DOI：10.1515/hc-2011-0106

• 2-alkynylquinoline-3-carbaldehydes
• benzo[b][1,6]naphthyridines
• microwave chemistry
• three-component reaction

A three-component reaction among 2-alkynylquinoline-3-carbaldehydes, primary amines, and chloroform leading to novel 1-(trichloromethyl)-1,2-dihydrobenzo[b][1,6]naphthyridines was developed using microwave initiation in an absence of any catalysts. This method provides a facile approach to the title compounds with moderate to higher yields.

• 出版日期2012-4