A Coxsackie B4 virus isolated in Yunnan in 2009 is a recombinant

作者：Zhu, Yanju; Pan, Yue; Chen, Junying; Liu, Jiansheng; Chen, Wei; Ma, Shaohui^*

来源：Virus Genes, 2015, 50(3): 375-380.

DOI：10.1007/s11262-015-1185-x

• Coxsackievirus B4
• Phylogenetic analysis
• Recombination

Coxsackievirus B4 is a member of the species Enterovirus B in the Enterovirus genus of the Picornaviridae family. So far, there are only seven complete genome sequences of CVB4 published in GenBank database. In the study, the complete genome analysis of a Coxsackievirus B4 strain A155/YN/CHN/2009 isolated from a child with aseptic meningitis in Yunnan Province was performed. It had 85.1 and 83.3 % nucleotide similarity with prototype strain J.V.B Benschoten in the VP1 region and the complete genome, respectively. Phylogenetic analysis of VP1 region showed that A155/YN/CHN/2009 belongs to Genotype V circulating only in mainland of China. The results of Simplot and Bootscanning analysis implicated that A155 has recombined with other HEV-B viruses.

• 出版日期2015-6
• 单位中国医学科学院医学生物学研究所; 中国医学科学院北京协和医院