科研之友
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摘要
Two casein plasteins were prepared from the Neutrase-catalyzed plastein reaction of casein hydrolysates in the presence of proline and phenylalanine, respectively, and assessed for their antihypertensive activities at 300mg/kg body using rat model. After being oral administered, the two plasteins at initial time of 2-6h resulted in the rats decreased systolic and diastolic blood pressures of 10-23 and 8-19mmHg, respectively; however, the measured antihypertensive activities showed decreasing trends as oral administrating time prolonged. The two plasteins also decreased serum levels of angiotensin II, angiotensin I converting enzyme, and aldosterone, but had unclear effect on serum angiotensinogen level. The two plasteins showed same antihypertensive activities without statistical difference (p>0.05), and were more efficient than casein hydrolysates but less effective than captopril (p<0.05) to exert antihypertensive effect. It is concluded that the plastein reaction can confer casein hydrolysates with enhanced in vivo antihypertensive activities.
