Amphiphilic PEG-Grafted Poly(ester-carbonate)s: Synthesis and Diverse Nanostructures in Water

作者：Zhu, Weipu^*; Wang, Ying; Zhang, Qiujin; Shen, Zhiquan

来源：Journal of Polymer Science Part A: Polymer Chemistry , 2011, 49(22): 4886-4893.

DOI：10.1002/pola.24944

• amphiphiles
• "click" chemistry
• graft polymers
• ring-opening polymerization
• self-assembly

Novel biodegradable amphiphilic graft copolymers containing hydrophobic poly(ester-carbonate) backbone and hydrophilic poly(ethylene glycol) (PEG) side chains were synthesized by a combination of ring-opening polymerization and "click" chemistry. First, the ring-opening copolymerization of 5,5-dibromomethyl trimethylene carbonate (DBTC) and epsilon-caprolactone (CL) was performed in the presence of stannous octanoate [Sn(Oct)(2)] as catalyst, resulting in poly (DBTC-co-CL) with pendant bromo groups. Then the pendant bromo groups were completely converted into azide form, which permitted "click" reaction with alkyne-terminated PEG by Huisgen 1,3-dipolar cycloadditions to give amphiphilic biodegradable graft copolymers. The graft copolymers were characterized by proton nuclear magnetic resonance (H-1 NMR), Fourier transform infrared spectra and gel permeation chromatography measurements, which confirmed the well-defined graft architecture. These copolymers could self-assemble into micelles in aqueous solution. The size and morphologies of the copolymer micelles were measured by transmission electron microscopy and dynamic light scattering, which are influenced by the length of PEG and grafting density.

• 出版日期2011-11-15
• 单位浙江大学